Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Fractalkine receptor / microglia-neuron communication: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CX3CR1 | participates_in | gene | 0.46 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Fractalkine Axis Amplification via CX3CR1 Positive Allosteri | 0.503 | neurodegeneration | Synaptic pruning by microglia in early A |
| Optogenetic Microglial Deactivation via Engineered Inhibitor | 0.384 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer's [PMID:39908361] | Wu X, Miller JA, Lee BTK, Wang Y, Ruedl | Sci Adv | 2025 | 1 |
| Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997] | Chen X, He X, Xu F, Xu N, Sharifi NH, Zh | Stroke | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237] | Subbarayan MS, Joly-Amado A, Bickford PC | Pharmacol Ther | 2022 | 1 |
| Microglia in neurodegeneration. [PMID:30258234] | Hickman S, Izzy S, Sen P, Morsett L, El | Nat Neurosci | 2018 | 1 |
| How neuroinflammation contributes to neurodegeneration. [PMID:27540165] | Ransohoff RM | Science | 2016 | 1 |
| Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged swor [PMID:41564496] | Liang J, Zhu W, Pan R, Wei S, Zhang S et | Cytokine Growth Factor Rev | 2026 | 0 |
| CD8(+) T(EMRA) cells: A double-edged sword in immunity and disease-Mechanisms an [PMID:41946125] | Ma J, Wu Y, Chen L, Zheng X | Int Immunopharmacol | 2026 | 0 |
| Aging effects on emotionality, cognition and brain mononuclear cells in Sprague- [PMID:41946716] | Djuretić J, Ivanović J, Jezdić K, Todoro | NPJ Aging | 2026 | 0 |
| Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects [PMID:41924777] | Mroue-Ruiz FH, Desai B, Garvin MM, Shehu | Biochemical and biophysical re | 2026 | 0 |
| Systems-level molecular and immunological evidence identifies Th17/Treg modulati [PMID:41788408] | ["Li X", "Li X", "Chen S", "Wang L", "Xi | Frontiers in aging neuroscienc | 2026 | 0 |
| Multimodal tumor thermal therapy enhances antitumor immunity by expanding tumor- [PMID:41799205] | ["Wang S", "Wang Y", "Zhang Y", "Zhang Z | Theranostics | 2026 | 0 |
| NIK-driven IL-23 production by myeloid cells is a key factor in the development [PMID:41758203] | Ramphal NS, Liu X, Palagi I, Jasser R, M | J Exp Med | 2026 | 0 |
| [Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acu [PMID:41930567] | Zhang Z, Yang W, Ying R, Shi Y, Jiang H | Int J Mol Med | 2026 | 0 |
| CX3CR1-T280M polymorphism and end-stage renal disease development in chronic kid [PMID:41932952] | Gatti M, Baragetti I, Baragetti A, Buzzi | Scientific reports | 2026 | 0 |
| Expression of MS4A4A on synovial infiltrating macrophages is a hallmark of rheum [PMID:41955527] | Asakura H, Matsueda Y, Ikeda K, Kyoda S, | Immunol Med | 2026 | 0 |
| Role of Cannabinoid Receptor Type 2 in Acute Behavioral Responses to Graft Versu [PMID:41958320] | Moe A, Liphart HA, Heaster K, Romero J, | Cannabis Cannabinoid Res | 2026 | 0 |
| SYK-dependent lipid handling in monocyte-derived macrophages governs functional [PMID:41831796] | ["Zhao Y", "Hu H", "Wang J", "Hu Y", "Ya | Brain research bulletin | 2026 | 0 |
| Microglial Lag3 Drives α-Synuclein-induced Neurotoxic Activated (A1) Astrocytes [PMID:41542562] | ["Yang X", "Kumbhar R", "Seo B", "Ha S", | bioRxiv : the preprint server | 2026 | 0 |
| Conserved ductular reaction mechanisms in biliary atresia and PSC derived from s [PMID:41903685] | Schofield A, Kamath BM, MacParland SA, T | Cellular and molecular gastroe | 2026 | 0 |